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In contrast, metabolite concentrations and reaction rates related to glucose metabolism changed in response to the blood glucose level and reproduced zonation patterns with the values consistent with the liver ( GK ), fructose-2,6-bisphosphatase (v FBP2 ), aldolase (v ALD ), glyceraldehyde-3-phosphate dehydrogenase (v GAPDH ), and pyruvate kinase (v PK ) compared with the periportal region, and the positive lactate dehydrogenase reaction rate was indicative of glycolysis promotion and lactate (Lac) production ( FBP1 ) and phosphoenolpyruvate carboxykinase in the cytosol (PEPCK, v PEPCK ), and glucose-6-phosphate phosphatase in the endoplasmic reticulum (G6P, v G6P_ER ) compared with the pericentral region ( PEPCKmito ) was higher in the pericentral region ( FIGURE 2 FIGURE 3 The glucose exchange rate by glucose transporter 2 in response to the external (blood) glucose concentration and the change of glycogen concentration over time was investigated to further validate the glucose metabolism model (Figure 4)
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Quantity:100 ml
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